病原：Rickettsiales-like prokaryote

宿主：Haliotis midae

主要癥狀：發(fā)病初期，沒(méi)有明顯的癥狀，發(fā)病持續(xù)一段時(shí)間后足部肌肉發(fā)白、出現(xiàn)水泡后出現(xiàn)潰爛表面有大小不一的潰爛孔。

RLP inclusion bodies (arrows) within infected digestive gland tissue of H. midae. Haematoxylin and eosin. Scale bar, 20 μm.

In situ hybridization of infected H. midae digestive gland with the species-specific probe combination P108, PRIK16SF and PRIK16SR. Arrows indicate RLP inclusion bodies showing positive signals. Scale bar, 20 μm.

In situ hybridization of infected H. midae digestive gland with the universal eubacterial probe EUB338 (positive control). Arrows indicate inclusion bodies showing positive signals. Scale bar, 100 μm.

In situ hybridization of infected H. midae digestive gland sample with the E. coli probe PEC109 (negative control). Arrows indicate inclusion bodies. Scale bar, 20 μm.

In situ hybridization of T. sarmaticus sample with the species-specific probe combination P108, PRIK16SF and PRIK16SR. Arrows indicate inclusion bodies. Scale bar, 20 μm.

(參考文獻(xiàn)：Rael Horwitz et al.,2016)